Valentijn IRIS - immune system responding to a "phantom" virus that is no longer active or replicating. Not sure how it happens but its a common manifestation in those who've taken HIV medications. So I got my PCR test back today. Negative. While there are always risks of false negative, the PCR for CMV is highly accurate in the presence of high IGM (assumed current active infection). High IGM and IGG with negative PCR tells me that my body thinks I have a virus that is't there. I also had high IGM and IGG for Lyme. Negative PCR and negative Western Blot. Every other possible pathogen they could think of? Negative too. Yet my CD8 is off the scale high. At this point I am leaning towards steroids to suppress this immune overactivity. Any thoughts?