Hello all - I have loosely affiliated myself with this web site as I do not know what my condition is, but it involves more than anything else - bodywide muscle fasciculations. As a side element of the fasciculations (going on 4 months now) I have developed sensory issues (burning, freezing) muscle spasicity in my calf that lasted 2 months then released, burning aching pain in my thighs, painful armpits and underarm areas, and extreme exercise fatigue. Despite this, with a very careful lifestyle change I am able to operate mostly normal, and do not have the extreme ongoing fatigue most of you face, nor do I have ongoing flu-like symptoms. Normal Brain, Spine, Neck MRI. Normal EMG. No clinical weakness or signs of Neuromuscular Disease. No signs of any disease in fact. To the point that doctors told me I was imagining things. I had nearly 30 tests run including ANA. Only test that showed positive, nearly 3 months ago now ... was CMV IGM and IGG. Doctors told me that was in no way causing bodywide fasciculations and all my other symptoms. And as mentioned, that was nearly 3 months ago. I had my CD4 and CD8 counts run: Absolute CD4 helper: 879 (range 359-1519) % CD4 Pos. Lymph: 33.8 (range 30-58) Absolute CD8 suppressor: 983 *HIGH* (range 109-897) % CD8 Pos. Lymph: 37.8 (range 12-35) CD4/CD8 Ratio: 0.89 (range 0.92-3.72) Lymphs: 51 *HIGH* (range 14-16) Neuts: 41 *ALMOST LOW* (range 40-74) Any immune system boosting supplements I've taken have immediately caused my twitching to go haywire, so I have always felt that the last thing I needed was to enhance my immune system. Additionally, taking Quercetin immediately gave me a sense of calm and relief throughout my system, though twitching didn't stop. Quercetin inhibits inflammatory cytokines. Doctors have been of zero help. So I have been trying to determine if I should be ENHANCING or SUPPRESSING my immune system right now. I am told that the above abnormal results imply possible development of AUTOIMMUNE DISEASE. From what I know about autoimmune disease, there is a period of time where you can possibly stop it from progressing to actual disease. But you have to catch it early. At this time I have no proper markers of actual disease processes in my body, aside from the above. So I am thinking that maybe I need to begin working on calming my immune system. Any help you can give me would be so much appreciated.