Last 4 months blood results MCV has gone from 100 to 102.7 to 103.2 to 104.7... despite being on Fredd's protocol since the 102 level MCH is still out of range and increasing RDW has shot up out of range with last test HGB, HCT, RBC in range but decreasing. All are consistent with deficiency of b12 and/or folate (as well as other nastier things) Paresthesias getting worse. Now have burning pains in palms. My doctor is now testing me for autoimmune hemolytic anemia and myeloma. My question is - is it possible for my results to get exponentially worse promoting methylation? Does methylation promote new red cell (Reticulocytes) production? As these cells are larger than mature cells, would this increase the MCV and RDW? Although following this, I guess my RBC would be increasing, not decreasing. Any theories?