caledonia
Senior Member
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For the reasons listed by liverock, you're taking way too much folate relative to B12. Sources such as Rich Vank or Ben Lynch suggest getting 3:1 or 5:1 B12 to folate. I believe Freddd suggests a 1:1 ratio.
So my suggestion would be to actually reduce your folate to be in line with the B12.
You have the B12 Double Whammy, which is both MTR and MTRR mutations, both of which affect B12, then also two MTHFR (folate) mutations. I guess it's a tossup as to whether that's going to make your B12 mutations worse than your folate mutations. So whether 5:1 or 1:1 is better - you'll probably just have to experiment.
With the COMT mutations, hydroxy could also be a better choice than methyl B12. Have some niacin on hand as you're experimenting, in case your methylation takes off and goes into overmethylation. The niacin will soak up methyl groups and save you a lot of suffering.
With COMT mutations also take it easy with TMG as it's another methyl donor (TMG = tri methyl glycine). In fact, Yasko suggests using sunflower lecithin to get TMG instead of directly supplementing TMG. It requires conversion to make TMG, and it's also a lesser amount, so it's safer to try. Plus you get some choline for cell membrane support.
Regarding folate burnout, that info was from MTHFRsupport. Sterling was a little cryptic in the way she stated it, but I believe she was referring to not only folic acid, but also methylfolate. So that's why I posted in on here, because I know a lot of people are experimenting with that.
See "Start Low and Go Slow" and "Roadblocks to Successful Methylation" in my signature below.
So my suggestion would be to actually reduce your folate to be in line with the B12.
You have the B12 Double Whammy, which is both MTR and MTRR mutations, both of which affect B12, then also two MTHFR (folate) mutations. I guess it's a tossup as to whether that's going to make your B12 mutations worse than your folate mutations. So whether 5:1 or 1:1 is better - you'll probably just have to experiment.
With the COMT mutations, hydroxy could also be a better choice than methyl B12. Have some niacin on hand as you're experimenting, in case your methylation takes off and goes into overmethylation. The niacin will soak up methyl groups and save you a lot of suffering.
With COMT mutations also take it easy with TMG as it's another methyl donor (TMG = tri methyl glycine). In fact, Yasko suggests using sunflower lecithin to get TMG instead of directly supplementing TMG. It requires conversion to make TMG, and it's also a lesser amount, so it's safer to try. Plus you get some choline for cell membrane support.
Regarding folate burnout, that info was from MTHFRsupport. Sterling was a little cryptic in the way she stated it, but I believe she was referring to not only folic acid, but also methylfolate. So that's why I posted in on here, because I know a lot of people are experimenting with that.
See "Start Low and Go Slow" and "Roadblocks to Successful Methylation" in my signature below.
My first dose like this felt like rocket fuel! My sense is that what I was experiencing was a histamine rush from the 'over-methylation'. It calmed after I took my anti-hist supps. I'm omitting my PM dose, which means today I'm taking 10 instead of 15mg. Will see how this goes in the next days. Happy Happy!