I'm trying to better understand my 23andMe results pertinent to the methylation pathway. Here's what I've been able to come up with so far (from reading Valentijn's recent comments on other posts): VDR Taq +/+ : "suggests that you're slow in producing catecholamines" MTR A2756G +/+ : "indicate a need for methylB12, and homocysteine may tend to be elevated" COMT V158M +/-, COMT H62H +/- : "Being heterozygous for COMT means you don't have the fast or slow versions for breaking down catecholamines, but are somewhere in the middle. " MTRR A66G +/- : "results in higher homocysteine and lower methionine. B12 supplementation may help. If sensitive to methyl groups at all, hydroxyB12 should be a safer form than methylB12. If taking methylB12, be careful of potassium issues." CBS C699T +/- : "results in slightly faster disposal of homocysteine. This is a very small up-regulation, and should not result in sulfur or ammonia problems." CBS A360A +/- : Relevant? I also have 4 NOS +/- SNPs. Does this indicate issues around Nitrous Oxide? I've attached my entire LiveWello report if anyone cares to dig deeper. I'm currently working my way slowly through the early stages of a methylation protocol, recently started on mild thyroid support with NDT, and have been working to address/heal adrenal dysfunction for the last two months. Things seem to be slowly improving, but not quite as fast as we all seem to hope they do. Thank you for any help/support.