Been trying out a few different things over the past few months, with no success. I tried addressing methylation, but all it did was causing me to crash horribly. I've experimented with probiotics -- Miyarisan, S. Boulardii, Custom Probiotics d-lactate, Reuteri. The more benign probiotics (Miyarisan and Boulardii) seemed to reduce subjective feelings of sickness/inflammation and improve sleep, but made me lazy and apathetic; the other two seemed to aggravate symptoms of inflammation and cause loose stools, weakness etc. My E.Coli levels on my stool test were normal, but I ordered Symbioflor 2 (e coli probiotic) to try regardless, since people seem to do well with Mutaflor. I also did a 2-week course of Flagyl and Ampicillin, which a gastro prescribed, but I didn't see any improvements. The lab who did the stool test has recommended to my GP that I do alternating one week courses of Azithromycin and probiotics for 8 weeks or so, but he won't prescribe the Azithromycin due to lack of evidence. So not sure what to do. The problem is that I go through brief phases where I have upticks in energy. But e.g. the last few days I can hit these crashes where I feel quite literally near-death ... I wake up choking for air, feel like just standing is draining every resource from my body, and that I'm running purely on adrenaline. So I get stuck, kind of just spiralling into this hole I can't get out of. The only thing I feel really keeping me alive is coffee enemas. I am thinking about maybe trying either: 1. GcMAF cream 2. Colostrum + lactoferrin When inflammation was reduced on the useful probiotics, that near-death feeling went away, so I'm wondering if either of those two things are worth experimenting with. Also, I was speaking to an online friend who studied biology and nursing, and she said it's ridiculous I haven't had any autoimmune diseases ruled out, given the severity of my CFS, and the fact that my brother has Chrohn's; she also mentioned my chronically high monocytes. Is this something I should be pursuing with my GP?