1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Give ME the Money
Graham McPhee spells out some of the cold, hard facts about the dismal state of ME research and politics, and has some suggestions as to what we can do about it ...
Discuss the article on the Forums.

Wisconsin Viral Research story

Discussion in 'Other Health News and Research' started by Omar88, Jan 20, 2013.

  1. Omar88

    Omar88 Senior Member

    Messages:
    335
    Likes:
    160
    http://www.wisconsinlab.com/virus_discovery.html

    Our interest in virus discovery began in 1988. In 2010, we are continuing this quest. Read about our ideas for the Global Virus Discovery Program in Kenya.
    Late in 1988, a positive but life-changing event occurred in the laboratory of Dr. Knox and
    Dr. Carrigan in the Department of Pathology at the Medical College of Wisconsin. They were asked by a fellow in the HIV/AIDS Program to try and isolate HIV from a patient's peripheral blood.

    The patient was an enigma. He was clinically suffering from AIDS (severe T lymphopenia, mental status changes, and life-threatening opportunistic infections), but he was seronegative for HIV and was negative for the HIVp24 antigen in his serum. A standard HIV isolation culture was established, but no HIV could be detected throughout the course of the culture.

    However, an unusual cytopathic agent was isolated (number 1 below). Standard virologic methods were used to confirm that the agent was a virus, and by electron microscopy this agent was identified as a member of the herpesvirus family. Further studies, in collaboration with Robert Gallo's laboratory at the National Cancer Institute, confirmed that the virus was a newly described form of herpesvirus termed human herpesvirus six (HHV-6). The surprise isolation of this almost unknown virus provided the inspiration for Drs. Knox and Carrigan's Program for Virus Discovery.
     
    Teedot, Little Bluestem, Enid and 6 others like this.
  2. 8eraser8

    8eraser8

    Messages:
    80
    Likes:
    13
    Hi Omar
    Thanks for this update, its really interesting, these 2 dr are great ppl, have u tried to contact them and ask them about testing?
     
  3. SOC

    SOC Senior Member

    Messages:
    5,364
    Likes:
    6,445
    USA
    You can learn more about hhv-6, including hhv-6a, at the HHV-6 Foundation. http://www.hhv-6foundation.org/ There's a whole section on hhv-6 and cfs.

    Some of us have been treated for hhv-6 and got some improvement.
     
  4. taniaaust1

    taniaaust1

    Messages:
    8,251
    Likes:
    5,216
    Sth Australia
    HHV-6A (most of the normal pop instead gets HHV-6B.. u usually get one or he other) has been strongly connected to ME/CFS with one study showing that nearly all ME/CFS people were carrying the HHV-6A version. As far as I know these studies were never followed up or it worked out why that was so.
     
  5. Valentijn

    Valentijn Activity Level: 3

    Messages:
    6,692
    Likes:
    10,146
    Amersfoort, Netherlands
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC172933/pdf/100521.pdf is a pretty interesting discussion of HHV-6 A and B, and provides a lot of specific info about HHV-6A, including increased prevalence in ME/CFS. There's even a section discussing CFS on page 29 of the pdf (page 549 of the hardcopy volume). It's still just 22% prevalence in one study, compared to 4% in controls, so while certainly interesting, it's probably not The Answer.

    There's a ton of links to other good papers about HHV-6 there, including two regarding ME/CFS:
    Di Luca, D., M. Zorzenon, P. Mirandola, R. Colle, G. A. Botta, and E. Cassai. 1995. Human herpesvirus 6 and human herpesvirus 7 in chronic fatigue syndrome. J. Clin. Microbiol. 33:1660–1661.
    Yalcin, S., H. Kuratsune, K. Yamaguchi, T. Kitani, and K. Yamanishi. 1994. Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome. Microbiol. Immunol. 38:587–590.

    http://cfs-ireland.com/hhv6a.pdf also mentions that 40% of ME/CFS clinic patients who had HHV-6A in spinal fluid did not have detectable HHV-6A in serum. So it might like to play hide-and-go-seek.
     
    Little Bluestem and Enid like this.
  6. Valentijn

    Valentijn Activity Level: 3

    Messages:
    6,692
    Likes:
    10,146
    Amersfoort, Netherlands
  7. SOC

    SOC Senior Member

    Messages:
    5,364
    Likes:
    6,445
    USA
    Read more here: http://www.hhv-6foundation.org/associated-conditions/hhv-6-and-chronic-fatigue-syndrome

    PS Who is surprised that Reeves is one of those who published a paper finding no connection between ME/CFS and HHV-6 using tests that don't distinguish between active and latent infections? :rolleyes:
     
    Valentijn and heapsreal like this.
  8. jstefl

    jstefl Senior Member

    Messages:
    167
    Likes:
    75
    Brookfield, Wisconsin
    The story of Wisconsin Viral Research, and Drs Knox and Carrigan is documented in a book titled" The Virus within" by Nicholas Regush. I would recommend this book to all. It is getting to be a little old, having been published in 2000, but it is filled with great information on HHV-6.

    Due to the age of the book, I was able to find it very inexpensively on used book sites. Abe books presently has many copies available for $ 1.00 each plus $ 2.95 shipping.

    The book is very easy reading, but will answer many questions about HHV-6, and its role in our illness.

    Dr. Knox is a very interesting person, and her inspirational story is worth reading on its own.

    John
     
  9. collegeusername

    collegeusername

    Messages:
    36
    Likes:
    7
    NY, USA
    This is what im saying! the herpesvirus family is responsible! how many of us have tested for all the hsv viruses?
     

See more popular forum discussions.

Share This Page