I have been working closely, from the beginning, with some people in the "wired and tired" (Thanks to Dannybex) characteristic. I am seeing some patterns and need some more information. I have reached an hypotheisis that I need to confirm or not as best as possible. Also, is anxiety a present? Is it aggravated by the following supplements or others? For those with huge response to mb12, adb12, methylfolate, l-carnitine fumarate (or other carnitine) and having done or attempted a titration of any size onto these items. Also, if the person has tried any benzos, their responses and also if they had anything like intradose withdrawal or "tolerance withdrawal" problems. For anybody willing, please give me your email address in a private message and I will send an excel spreadsheet set up as a lifetime history of symptoms for all the symptoms on the list. I will be basing it on an updated list from what is already posted. I believe I have a correct analytical solution and a possible protocol but I need more information to be sure.