I know that I have a biological disease. I know that this disease is making my life unbearable. I know that I feel a lot of pain. I know I don't get enough quality sleep. I know that I have been put on anti depressants in the past and none have helped me. but, I also know that many times I go through stages where I feel no hope and the pain is so intense that I see no end at the tunnel and given a choice, I'd rather just check out. I definitely feel depressed at those times. I know that it's an outcome of being ill but other people who are clinical depressed, I'm sure also have a reason to be depressed. What's the difference between my feelings of depression and theirs? There are times when I don't look forward to do anything because I know it's going to cause me more pain. Sometimes I feel like there is no way out of this. Isn't that what clinical depressed people feel? I know we are all afraid of that word because it has been used against us to try to undermine our illness but couldn't it be a comorbid condition for some of us? I don't think it takes away from the gravity of CFS. The opposite - I think it's a testimony to what an awful illness it really is. I know for me the worse I feel, the more depressed I get and the more depressed I get the worse my CFS symptoms get. Like a vicious cycle. Anti depressants have not helped me (at all) but, there is such a thing as medication resistant clinical depression. Why are we so afraid to admit that at times we feel depressed? We are perpetuating the stigma associated to a very real disease too. Clinical depression is very real and painful illness. What we are doing to the clinically depressed is what the medical establishment is doing to us. Ignoring the legitimacy of the disease.