It is mysterious... When I started acyclovir, I got a flu, after a few days it went away and I felt better afterwards. Thereafter I got the shingles. Now on LDN I get big neck cramps suggesting some sort of viral brain infection flaring up. I could give many more examples both from my own experience and from other people's stories: when you hit em, infections seem to become worse initially. Why is this? My theory is that these infections are lingering in the background and then when your immune system picks up, then it starts fighting them and the symptoms that are common for these infections (when you have a functioning immune system) become apparent. So its not actually flaring up of the infection, but of the immune system. Any other suggestions? And what to do when these symptoms flare up? My intuition is too stick to your treatment, as your system is now trying to get rid of the infection,as a normal healthy person would do Whats your take on this?