Niacinamide makes me drowsy so I take it usually at bedtime or during the night. (1) After taking 250mg niacinamide it actually makes me more alert for an hour and prevents sleep during this time. Sometimes I might take it with 800mcg of methylfolate and 500mcg of methylcobalamin B12. (2) After the alertness I go to sleep. A couple of hours later, at normal waking up time for me, it is unusually hard to wake up from sleep and I feel sedated when I get up. (3) After waking, vitamin B-1 (100mg) and vitamin B-2 (100mg) taken together seem ease to the drowsiness although maybe the drowsiness was wearing off on its own - it's hard to tell. Is this strong sedation something to do with methylation? What are B-1 and B-2 doing that reverses the drowsiness? Can anyone kindly advise. Please keep any information simple because I have tried to understand methylation from some of the discussions here but it never seems to make clear sense to me. Thank you. PS: I happen to take methylfolate (2,000mcg) and methylfolate (3,500mcg) throughout the day and they usually help a lot to make be focus better.