Bob, JM claimed to have found virus using simple techniques. Of course those many labs that dropped some part of what they were already doing, followed up the Science paper, tried to confirm and perhaps extend JM's (alleged) work - and found it didn't work. Now, it seems, we know why. JM claimed "XMLV is expressed in the activated PBMCs of CFS patients." That is the claim that people were confirming and trying to follow up. You're asking them to have umped to look for something else that she didn't claim? 5AZa and demethylating agents find lots and lots of things. Even the experiment I describe isn't definitive - If one finds some kind of virus-like expression, one still hasn't ruled out that CFS makes PBMCs respond differently to demethylation. That also is a reasonable hypotheses - remember, this is a p neuro-immune disease, and it makes the immune system act differently. That would be a preliminary experiment, start of a whole ton of work, and no lab is going to commit several people to that work, instead of something currently productive, without evidence that there actually is a virus. Right now - there is no evidence that there actually is a virus. What there is, is evidence the JM et al made claims that were not true and that they cant support. That's part of the tragedy here - no one knows what might be real and what is made up, and it is going to be a rare lab that, given a choice of productive work they have going that is leading toward helping people, and pursuing this work on CFS which they have no way to know actually ever really happened - is going to choose this path. I hope that part of the investigation goes through JM et al's notes and results and tries to identify if some of what JM did is actually real. I hope more work toward trying to identify causes of CFS goes forward. Virsu screening - broad-based, not just following up this s*storm - should be pursued. It looks like the funding and some labs are going there. There are interesting hypotheses about persistent activation of ERV expression, which I think is ongoing and worth pursuing. But following up the JM stuff? I wouldn't do that, fi I were running a lab and choosing research directions and wanting my lab to be funded and active and successful n 5 years. Not now, not after this.