I see so many people on this board, including myself, experience this. I almost feel normal at night. Surely, if the reason for this phenomenon was investigated maybe we could come closer to finding an answer to this syndrome? When I think of all the times I had an infectious disease, I in fact feel the worst at night time, even with the common cold, I dread the way I begin to feel when night time hits. But this disease; it's almost the opposite. Makes me wonder if an infection is really behind it at all. I've also spoken to many people with mood disorders as well who've said they feel better at night. The conditions must share something in common in terms of the pathological process.