Hi! What I really don't understand is why I'm feeling always less exhausted in the evening than the rest of the day? My cortisol is normal in the morning 7.32 (ref.range 2-10), low in the afternoon 1.41 (1.55-6) and very low in the evening 0.29 (1.15-4.85). I also feel this kind of hard to describe crippling pain when cortisol is low. It's near kindeys/low back, it's kind of a dragging and constant pain - no matter if I am in bed or move arount - and it's radiating into the whole area in the midth of my body. As soon as I am able to sleep the pain and the exhaustion get better. So it's clearly energy-dependent. When I catch up enough sleep my cortisol levels are more in the low to normal range. So it's sleep dependend. But in 2 years I did not have one single night of normal sleep, I usually sleep about 3-5 hours, it's a dream disturbed and fragmented sleep. It's like I sleep about 2-3 hours normal, then I wake up and sometimes, after hours of lying awake, I fall into a fragmented and very light dreamy sleep So why is it that I feel terrible in the morning and energy increases in the evening? Shoudn't it be the other way? Serototonine is normal to high, dopamine is too high and arenaline is too low (due to methylation issues). No current viral reactivations at this time. I also have problems with food sensitivities and chronic histamine issues (probably due to slow HNMT and a lack of methyl groups which are needed to break down histamine). Anybody else?