This is an experiment I would like to conduct here in the forum to test the hypothesis that using Turmeric, an anti-inflammatory supplement that restores the PI3 but inhibits the NF-KB inflammatory cascade pathway will have a noticeable effect in increasing inflammation and fatigue which is alleviated by administration of the protective supplement Milk Thistle. These pathways are known to be blocked in neutrophils (white blood cells involved in immunity) when L form bacteria infect them. (Faherty 2008) The exercise uses a crossover approach and is unblinded. If the hypothesis is null that L form cause CFS then then turmeric alone will likely improve patients with CFS because is anti-inflammatory. If hypothesis is not null turmeric will worsen symptoms. Materials you will need: A patient diagnosed with chronic fatigue syndrome 1 small bottle of Milk Thistle supplement standardized for silymarin 1 small bottle of bioavailable turmeric supplement standardized for curcumin (needs to be either a phospholipidized form or with 5 mg of additional supplement bioperin for good absorption. If you buy an additional bottle of bioperin you can split the capsules with a pill splitter and seal them with food grade wax but for ease of use I recommend getting phospholipidized turmeric if available). (Note-a great place to buy supplements is Swanson Vitamins online) Method Make sure your omega 3 level is adequate. Most people need 2-3 tablespoons of flax oil with fiber per day taken at breakfast. 10% of the population can't transform the EPA in flax. You can test for this by noting depressed mood and dry skin. If flax supplementation is working (and dose is correct) these rapidly improve in a few days. Otherwise you can use Chia seed extract which is more expensive but useable by anyone. ATTENTION:THIS IS A NEW PROTOCOL. MODIFIED AS OF 9/23/2010. Before taking supplements (and any anti-inflammatory medication) note your baseline of inflammation symptoms. List symptom (i.e. intermittent headache, fatigue, quality of sleep), how often it occurs and severity (0 none -10 worst). Do this for a minimum of two days to get a level baseline. Also list when and the dose of any anti-inflammatory medication you need for pain management. If symptoms are changing keep tracking them until they level for two days. First take 1 capsule of Milk Thistle every 8 hours (3x per day). Do this for two days noting your symptoms. When they are stable move to the next step. Keep taking milk thistile but now add 1 capsule of turmeric every 12 hours. As they appear note symptom changes (increase, decrease) and list new symptoms. Stop tumeric when symptoms are stable unless intolerable. If the milk thistle helps you discuss continuing it with a knowlegeable health care professional. Post your progress and results here.