Many people on this forum have had their genotype determined by 23andme.com, and by means of the Genetic Genie website, have become aware of the SNP mutations they have within their methylation cycle genes, and their detoxification profile genes. In the light of this knowledge, a fair number of people on this forum have attempted to compensate for their SNP mutations (flaws) by taking appropriate supplements or making dietary changes which support the metabolic pathways connected to their mutated SNPs. In this thread, could those who believe they have gained real noticeable improvements in their health from such compensating supplements or dietary changes kindly post the details. When you posts these details, please can you state: • The particular SNP mutation you are compensating for (for example: MTHFR A1298C), and whether you are homozygous (+/+) or heterozygous (+/-) for that mutation. • The supplements or dietary changes you used to compensate for that SNP mutation. • The noticeable benefits in your ME/CFS, anxiety, depression, etc, symptoms or your general health that you think you gained from these supplements or dietary changes. • Optionally, you may want to add a biochemical explanation detailing how the supplements or dietary changes you used work to compensate for the SNP mutation. If you do this, please provide links to the scientfic sources of that biochemical theory. The idea of all this is to: (1) To see how many people have derived noticeable health benefits as a direct result of having had their SNP mutations determined by 23andme.com, and by subsequently using supplements and/or dietary changes to compensate for these mutations. In other words, to see whether taking this 23andme.com SNP mutations test is actually useful or not for those with ME/CFS. (2) To turn this thread into an informal database of supplements and dietary changes that can be used to successfully compensate for each specific SNP mutation. This database will then allow anyone who has had their SNP mutations determined to see which of these can be successfully compensated for, and which supplements or dietary changes are necessary in order to do so.