Hi everyone, I began on meb12 (the Enzymatic Therapy Chewable B12 sublingual tablets touted so regularly here) a week ago (beginning on 1/4 tablet for three days, then 1/2 for 4 days, and today I'm up to 1) and Solgar Metafolin (l-methylfolate) 5 days ago. If it's of any importance, I had taken BetterYou B12 spray (the one with chromium and green tea extract) a few times previously, but not consistently, over the last fortnight. I began on fish oil vitamin A two weeks ago, as I have systemic candida and apparently vitamin A in the fish oil form needs to be supplemented in this disease. I didn't note exactly when the coldsore-like lesions began appearing, but it definitely coincided either with the meb12 and/or the metafolin. It began with one on my lower lip and this morning I woke up with what appears to be angular chelitis; tiny clusters of sores at the corners of my mouth. I've noticed that that my tongue has also gone white; although to be fair I've had white patches on my tongue for over a year, but never as bad as this. I have been taking adob12 (HHI MegaDrops) and l-carnitine (Jarrow Formulas liquid freebase) for several weeks, too. I wasn't noticing any benefits from them, so I decided to add the other members of @Freddd 's deadlock quartet. I'm wondering if starting on the methyl supps has induced a deficiency elsewhere? The wikipedia article lists numerous nutritional deficiencies and conditions, most of which I have and am taking supplements for (zinc picolinate; copper citrate; b1, b2, NADH, b5 (in the Jarrow l-carnitine), whether or not they're being absorbed I do not know, and as I cannot find transdermal forms I'm stumped for what to do), but I've never experiencied angular chelitis until now. Could it be a biotin deficiency, or a requirement to increase my other b vits? Any help would be much appreciated.