Wondering if anyone can offer any insight. I'm 6 years post RAI for Graves Disease and whilst now finally on NDT with good thyroid labs I've been left with ME. One theory is that to have had extremely low T3 levels for 3 years whilst on levothyroxing only have left the microglia so upregulated that this is what's at the root of the crisis in my body. An advisor from the States I was working with suggested trialling low-dose Valcyte as he has heard it's working well for people with CFS without the extreme side-effects of more normal Valcyte doses. I have had EBV in the past and gut issues but I believe this severe endocrine crash (when my thyroid was destroyed) and resultant disrupted hypothalmic-pituitary axis signalling is the most significant issue. I think it's pitched me into early menopause too - I'm now 46. I live in London, will very happily travel to see a doc but I'm just not sure who is the best one to see? I have been asking Kenny De Meirlier's office if he treats with low-dose valcyte and is experienced with hormonal and HPA signalling issues but I've heard nothing back. I've asked to join the patients of Kenny De M section here on Pheonix Rising but have heard nothing and can't get on this blog. I'm interested in Jack Kruse's information on adrenal fatigue I found on the forum here - but it would be great to hear from someone who has been treated by him and if that's indeed possible? https://www.jackkruse.com/brain-gut-16-adrenal-fatigue-rx/?fdx_switcher=true Also interested in Dr Kaufman. Any thoughts really gratefully appreciated. Anyone with similar history had any success with a particular route. Am just finding it mind boggling to know what to try next as have been through all the CFS docs in the UK and got nowhere.