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Which cytokines to test for?

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by svetoslav80, Apr 3, 2014.

  1. svetoslav80

    svetoslav80 Senior Member

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    I finally have some money and on my next crash, I'm going to make a cytokine pantel test. I hope I find a proper laboratory for this in my city. But I need an advice. Which cytokines to test for? Which cytokines are typical for fatigue. I think IL1, IL-2, TNF-alpha (maybe), and I've heard that IL-10 is typically in big quantities when one has hangover, a symptom which is the worst for me. I'm going to pay for the test by myself so I can't allow too big number of cytokines. Maybe about 5. Any suggestions?
  2. SOC

    SOC Moderator and Senior Member

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    I can tell you which ones Drs Klimas and Rey routinely test, if you want to know.
  3. svetoslav80

    svetoslav80 Senior Member

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    Of course I would like to know, please share with me.
  4. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    Do you have a basic pro-inflammatory cytokine test available? That might give you some of the basics though most of the specialists do test for more than that.

    The other question is do you or a doctor you work with know how to translate cytokine results into treatment? Or would it be more for diagnostic information?

    Sush
  5. svetoslav80

    svetoslav80 Senior Member

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    Hi Sushi,
    I don't work with a doctor, I decided to make the test by myself. It will be just for diagnostic information. I'm not a typical CFS patient. I know that for CFS, most cytokine levels are normal. But in my case, I hope there will be some findings. What means If I have a basic pro-inflammatory cytokine test available? Is it a test that I buy and do by myself? If so, no I don't have one. I'm also not sure If I can find one here in pharmacies.
  6. SOC

    SOC Moderator and Senior Member

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    Proinflammatory Group
    TNF-alpha
    LT-alpha (TNF-beta)
    IL1 alpha
    IL1 beta
    IL6
    TNF RI

    Th1/IL-8 Group
    IFN-gamma
    IL12
    IL2
    IL15
    IL8
    TNF RII

    Th2/Th17/Anti-inflammatory Group
    IL4
    IL5
    IL17
    IL23
    IL10
    IL13
  7. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    Some labs offer a pro-inflammatory cytokine panel. Panels may be less expensive than requesting individual cytokine tests. In the US you would get a kit from the lab, go directly to the lab with a lab requisition, or to a doctor who would send your blood to the lab.

    It works differently in each country I would guess. I got a kit from a lab (a doctor had to sign the requisition), got my blood drawn at a hospital, and sent the kit to the lab.

    Sushi
    svetoslav80 and SOC like this.
  8. SOC

    SOC Moderator and Senior Member

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    My cytokines sure as hell are not normal, and neither are my daughter's. I suppose it depends on what cytokines you're looking at.
    svetoslav80 likes this.
  9. lnester7

    lnester7 Seven

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    Be aware, Mine are different every time. Some are consistent every time. But Mine are all over the place, specially the inflammatory ones, and you need to know how to interpret the whole picture.

    Also just a thought, you can pay very little for a phone consultation w some CFS Dr like Enlander to give you some list or guidance to start.
  10. svetoslav80

    svetoslav80 Senior Member

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    This is very useful, thank you.
  11. SOC

    SOC Moderator and Senior Member

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    Same here. I have some that stay consistently normal, one that's consistently high, some consistently low, and others that change dramatically from one visit to the next. It may have something to do with what meds or supplements I'm taking, or it may have nothing to do with anything I'm doing.

    It might take an immunologist (or an experienced doc like Dr Enlander) to interpret the results.
  12. Valentijn

    Valentijn Activity Level: 3

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    Extremely elevated IL-8 seems somewhat common on the forum, so might be interesting to test for.
    svetoslav80 likes this.

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