Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
Discuss the article on the Forums.

Where can I find more info on MAO-A s1137070?

Discussion in 'Genetic Testing and SNPs' started by Peyt, Jun 26, 2016.

  1. Peyt

    Peyt Senior Member

    Messages:
    410
    Likes:
    114
    Hi,
    Is there any information that shows which supplements would help this SNP(if activated)?
    Particularly looking for supplements that can help convert Norepenephrine to it's next cycle(so it does not build up). Magnesium Citrate is somewhat helping by reducing my anxiety and improve sleep at night (Natural Calm) but I am hoping by understanding this SNP better I might be able to find some more supplements that helps this issue. Particularly blood vessel constrictions and blood flow reduction in the kidney and throughout the body that is caused by Excess NE buildup.
    Thanks so much.
    Peyt
     
  2. Valentijn

    Valentijn WE ARE KINA

    Messages:
    14,283
    Likes:
    45,782
    Both variants of that SNP create exactly the same result. It does nothing.
     
  3. ahmo

    ahmo Senior Member

    Messages:
    4,329
    Likes:
    6,507
    Northcoast NSW, Australia
    maddietod likes this.
  4. Peyt

    Peyt Senior Member

    Messages:
    410
    Likes:
    114
    That's not the point.... Even if this SNP means nothing it still does not negate the fact that some people have excess NE that is causing problems for them.
    Do you know anything that can help with excess NE??
     
  5. Peyt

    Peyt Senior Member

    Messages:
    410
    Likes:
    114
    Thanks for your post.
    So based on this diagram: https://i2.wp.com/selfhacked.com/wp-content/uploads/2014/12/Screenshot-2014-12-08-23.44.16.png
    COMT and MAO work together as far as Dopamine and NE is concerned. Unfortunatly I have both COMT++ and 1 MAO++

    According to this study Magnesium inhibits norepinephrine release by blocking N-type calcium channels at peripheral sympathetic nerve endings: http://www.ncbi.nlm.nih.gov/pubmed/15477382
     
  6. Valentijn

    Valentijn WE ARE KINA

    Messages:
    14,283
    Likes:
    45,782
    If it's not the point, why is the title about that SNP? And your post states that you want to understand more about this SNP, so I explained that the SNP does nothing.

    I answered what seems to be your primary question, so maybe you could explain why you don't actually care about it. Or maybe you have a completely different question which actually has nothing to do with SNPs?
     
  7. Peyt

    Peyt Senior Member

    Messages:
    410
    Likes:
    114
    I don't care about it because you seem to answer this for every snp question and post on this site and since I have basically changed my life just by addressing my CBS++ using info on this site and hearfixer I don't believe your claims of these snps doing nothing is actually correct(and i don't give a crap about the research, my own life is the best research there is out there for me) . It was my mistake to even reply to your comment. I should have ignored it.
     
  8. Valentijn

    Valentijn WE ARE KINA

    Messages:
    14,283
    Likes:
    45,782
    Interesting. Please do explain how a synonymous variant in the coding section of a gene has an impact on the functioning of that gene. It would also be nice to know why you believe the research into the harmless SNPs is faulty.

    Just because a treatment works for some people, doesn't meant that a specific cause is proven. And in the case of the Yasko CBS SNPs, etc, that cause is actually disproven, so it makes much more sense to look elsewhere for a cause.
     
  9. alicec

    alicec Senior Member

    Messages:
    1,370
    Likes:
    2,669
    Australia
    It's entirely your prerogative to believe that the world is flat but, if you do, you can't expect anyone else to take you seriously.
     
    Last edited: Jun 27, 2016
    Valentijn likes this.
  10. Peyt

    Peyt Senior Member

    Messages:
    410
    Likes:
    114
    Is this why I am getting messages from members in my mailbox in regards to lowering NE? One of them said she prefers to send me the info privately so she does not have to deal with antagonistic people on this board.. wonder who those might be!
     
  11. alicec

    alicec Senior Member

    Messages:
    1,370
    Likes:
    2,669
    Australia
    I hope that some of the suggestions help you. I agree that excessive production of NE can cause problems, but this has nothing to do with the SNP you were asking about.
     
    Valentijn likes this.

See more popular forum discussions.

Share This Page