Rich, Thank you for your generous contributions to our forums. From an orthomolecular point of view, do you see any relationship between a ME CFS patient (me) whose symptoms started with chronic neck pain. The dorsal root ganglia is a focus for me because my spine feels like it is on fire for the last 8-9 years. 3. Dorsal root ganglionitis--Due to infections as a result of the immune dysfunction that in turn results from the vicious circle mechanism. Glutathione depletion inhibits the cell-mediated immunity, and the disruption of lowered levels due to the HPA axis dysfunction allows inflammation to increase. In November 2010 my lab results indicating that on top of being XMRV positive (sept 2010) I tested positive for HHV-6 ( 3.45), Chlamydia Pneumoniae AB IGM (>1:256), Cytomegalovirus AB IGG CMV IgG (3.1), anemia (on going) High C-Reactive Protein, Vitamin D defiency (29), (in spite of taking 3,000 I.U. a day!) Low DHEA Sulfate (15.0), Mycoplasma Pneumoniae IGG AB (104) Low Testosterone (258) on going, and it suggestive of a past Epstein Barr Virus infection. I went off valcyte after 14 months in 2012. It did help. I am waiting for Nagalase levels to come back from Belgium. Like others who post here I am of the walking dead making way through life. I went off all pain meds in Dec 2011. The pain is in my spine and my muscles. Any insight you might be able to shed would be appreciated. I have a sister who had 4th stage Lymphoma at 19 who just passed (54) and a sister with Chrohns that had started Epstein Barr when she was 16. Again thank you for your dedication and Posts!.