Hello, I'm new here; I would love insight into my question below. I'm reading Yasko's book and have read previous posts, but there's so many variations I can't keep it straight. My 23andme results are: BHMT-08++ CBS+- COMT++ DAO++ FOLR2++ MTHFR A1298++ a lot of other MTHFRs are ++ or +- (but C677 is --) MTHFS ++ NOS3++ SHMT1++ I want to make sure i'm on the right path b/c things have been up and down for me. One dr. told me to take active b-12 and folate based on the a1298++; at her direction, I took full doses of both and ended up in a huge mess for the first time. I found a new dr. who knows this better, and I'm trying to correct things. I've been off sulfur for 3 months. I think that's cleared, but I am now having issues with ammonia. Am taking butarayte and just ordered l-orthinine to help. also started yasko's SHMT spray and take, zn, mg, vit d and probiotics. My new dr. wants me to add in iodine drops, sunflower leftin, lithium oratate, b2 and b6. He said a few wks later I can add B12 as adenosyl and then methyl b12. After that would be methyl folate. I will start one at a time, with very small doses. My question is should I let the ammonia clear before adding the b2 and 6....am I moving too fast? I'm just scared after the impact when I had the wrong guidance and created a terrible problem. After the sulfur issue seemed to clear, I drank a couple glasses of wine and realized that the sulfur must convert to ammonia b/c my head's been weird again. Thank you.