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What's your CD4/CD8 ratio?

Discussion in 'Immunological' started by SOC, Sep 11, 2013.

  1. SOC

    SOC Senior Member

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    Just wondering if there's any commonality among us -- low, normal, or high.

    My CD4/CD8 is high -- 6.3. My daughter's is normal -- 2.2. So no pattern there. ;)

    Anybody else wanna chime in?
     
  2. merylg

    merylg Senior Member

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    Sydney, NSW, Australia
    My CD3 T Cell....................2.23 (0.7-2.1)
    CD4 T Helper Cell.........1.64 (0.4-1.4)
    CD4/CD8 Ratio..............3.12 (1.0-3.0)
    'Mild reactive changes'
     
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    reference ranges here in oz for cd4/8 ratio are 1-3.5
    my tests have ranged from .85 to 1.6
    in saying that my individual cd4 and cd8 have mostly been elevated especially cd8.
     
  4. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    Mine is 2.64. It has stayed almost the same in the 3 years it has been tested.

    Sushi
     
  5. Mij

    Mij Senior Member

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    My CD4/CD8 Ratio is 2.3 (1.0-1.5)

    CD4 533 (700-1100)
    CD8 234 (500-900)
     
  6. SOC

    SOC Senior Member

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    Looks like I'm the oddball here. :D My CD4/CD8 ratio is high because my CD8 is low. I'll have to go dig out numbers...

    I'm also oddball in that my NK cell function started normal and is now high, unlike many other patients (including my daughter) whose NK cell function is low.
     
  7. Lala

    Lala Senior Member

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    Mine was high and normalized with treatment.
     
  8. SOC

    SOC Senior Member

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    Care to share what treatment lowered your CD4/CD8 ratio? [Hoping it's one I haven't tried yet ;)]
     
  9. SOC

    SOC Senior Member

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    My raw numbers:
    2012:
    CD4: 869 (range: 595-1199) NORMAL
    CD8: 160 (range: 219-731) LOW
    CD4/CD8: 5.43 HIGH
    CD56: 232 (range: 98-294) NORMAL
    NK cell activity: 19.08% (range: 5-21) NORMAL

    2013:
    CD4: 951 (range: 595-1199) NORMAL
    CD8: 150 (range: 219-731) LOW
    CD4/CD8: 6.34 HIGH
    CD56: 172 (range: 98-294) NORMAL
    NK cell activity: 26.50% (range: 5-21) HIGH

    Daughter 2012 (2013 results pending)
    CD4: 999 (range: 595-1199) NORMAL
    CD8: 460 (range: 219-731) NORMAL
    CD4/CD8: 2.17 NORMAL
    CD56: 30 (range 98-294) LOW
    NK cell activity: 4.25% (range: 5-21) LOW

    One thing I find interesting is that while we had the same very sudden onset flu-like illness at the same time (although different illness paths), our immune results are very different. As best I understand (and that isn't very well), my daughter's immune results are more typical of ME/CFS, while mine are more indicative of high viral load. At the same time, she is currently fully functional, while I'm still substantially impaired although vastly improved from Valcyte treatment. I wonder if this doesn't suggest that I'm still fighting an as-yet-unidentified virus.
     
  10. Lala

    Lala Senior Member

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    Antibiotics. Impaired CD4/CD8 ratio is common sign of lyme and co. or at least this is what my doctor told me.
     
    merylg likes this.
  11. Thinktank

    Thinktank Senior Member

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    Europe + South East Asia
    CD4/CD8(FACSCAN)
    WBC count 7240 cells/mm^3 ref range = 5000 - 10000
    lymphocyte 37% HIGH ref range = 20-35
    CD4 42.99% ref range = 31.00 - 60.00
    Absolute CD4 count 1139 ref range = 529 - 1351
    CD8 29.99% ref range = 13 - 41
    Absolute CD8 count 795 ref range = 454 - 1028
    CD4/CD8 ratio = 1.43
     
  12. Mij

    Mij Senior Member

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    A friend of mine who suffers from severe chemical sensitivities and allergies (with no viral CFS onset) also has a high CD4/CD8 ratio, very low lymphocyte count (lower than mine actually) So it can caused by a number of issues.
     
    SOC likes this.
  13. SOC

    SOC Senior Member

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    Thanks, Lala. I've been tested and found to be negative for Lyme, but I'm now wondering if I need to be retested. I know I've been bitten by ticks (although it was a long time ago), so Lyme is not entirely out of the question.
     
  14. Thinktank

    Thinktank Senior Member

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    I've never been tested for Lyme but have been bitten by ticks around 50 times or so.
    In my childhood I was always playing in the woods which was infested with ticks, i often came home with those bloodsuckers so my mom took them off me. Can it be that lyme stays dormant for years and pop up 15 years later creating havoc?
     
  15. stephano75

    stephano75

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    Just dug out test results from 2012
    High cd 4
    High cd4/cd8 ratio
    "Mild reactive changes" etc.

    I also found test from 1998...which showed similar thing- high cd4 and high CD3...but npot high CD4/CD8 ratio.
    "Response to subacute virus /inflammatory response" etc
     
  16. Thinktank

    Thinktank Senior Member

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    Does anyone know what the usual CD4, CD8 and C3, C4 numbers are in people with chronic lyme's?
     
    SOC likes this.
  17. ssgklein

    ssgklein

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    hi my cd4/cd8 ratio is 11.6 to 1 don't know why had all kinds of tests. Had enlarged lymph nodes in groin everything came back normal. Surgeon said it was cat stratch but had no other symptoms.
     
  18. Gingergrrl

    Gingergrrl Community Support Volunteer

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    What does CD4 and 8 ratio mean? How do I get tested for this? If I asked this question in a previous thread, my brain did not retain the info! :bang-head:
     
    WillowJ likes this.
  19. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Cd4 and cd8 are a type of T cell lymphocyte. Generally activated during an infection. To get these tested u need to ask for a lymphocyte sub set test. May have different names in different countries. Can use it as evidence that u have immune dysfunction going on.

    Most GPs aren't use to reading or ordering these tests.
     
  20. ashler

    ashler

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