Hello everyone, I've been reading on this wonderful forum for a few months already. Hoping to find something that will help me to feel well again... I'm 46, and going through perimenopause. Since 18 months, I'm suffering of terrible anxiety/depression. I also have 'adrenaline rushes' when I wake up en when I go to sleep. I can open a shop with all the supplements I've already tried... Today I received the results of a urine/blood-test. Can someone please help me to interprete them? Urine: Dopamine: 288 (137 - 338) Homovanilline acid: 3 (2 - 4,9) MHPG: 1,4 (1,4 - 5,10) VMA: 2,6 (2 - 4) Serotonin: 70,9 (41 - 120) Noradrenalin:: 40 (17 - 40) Adrenalin: 4,19 (1,7 - 6,6) Metanefrine: 121,9 (41 - 91) Normetanefrine: 145,8 (103 - 230) Blood: Cortisol: 21,5 (7 - 25) Transcortin: 67 (20 - 50) Free Cortisol: 8,5 (10 - 30) ACTH: 20 (must be lower than 46) Vitamin B6: 86 (88 - 456) My omega 3 also is too low. My homocysteine was 6,8 and last year 5,1. Vitamin b12 was 567 Folic acid in rbc: 226 I ordered a 23andme test to see if there is something wrong with my methylation. Didn't receive the results yet... Please, I do feel so awful. Does anyone has some good advise for me? Seems like there is something going on with my adrenals, although my total cortisol is fine. I can't live with this anxiety/ depression anymore. But I'm afraid of taking regular meds like antidepressants because they mask a symptom, but don't cure the cause. Thanks in advance!