I'm new to this forum and am finding navigating a route to improved health is a huge uphill struggle. I have had chronic back and neck pain for over 20 years and have been taking levothyroxine for a good 10 years for an underactive thyroid. Over the last 3 years, I have been suffering with gut pain and issues. I have had all manner of tests, including the breath tests and have been diagnosed with SIBO and also presence in my gut of blastocystis hominis. I have had genetic testing by Genova Diagnnostics and this has come back saying I have a polymorphism on my CYP2C9 chromosome, I also have 2 chromosomes that carry the NAT2 polymorphism and 1 chromosome that carries the COMT polymorphism. I never thought that I would be deciphering my own genes in this way and wish I didn't have to! I am currently taking Lamberts vitamin E 400iu, Biocare Zinc citrate, Vitamin D spay, Better you magnesium spray, Biocare mega EPA, Biocare peppermint complex. I have also been taking high doses of Nutriadvanced berberine and grapeseed formula to tackle the SIBO. I seem to manage okay and all the above, though they do not offer a solution to my issues. I have tried Allicin, Turmeric, molkosan, triphala etc etc! Nothing is working for me. My nutritionalist advised me that it was crucial to try taking methylfolate and methyl B12 as this was something that my body needed and could not make itself, due to my genetic issues. I tried Biocare Nutrisorb methylfolate and methyl B12, as well as nutri advanced multi essentials one a day multivitamins, which include vitamin B12 and L glutamine. Taking any of these made me feel terrible and so I have stopped trying with that. I also tried NAG and slippery elm, but both gave me weak legs and so I had to stop that too. I will stick to taking my vit E, D, zinc, magnesium, mega EPA, but beyond that, I am getting to the point of feeling like maybe it's best to lay off trying all these other supplements, which not only haven't helped, but have made things worse! Sorry this is a rather rambly post, but just wondering if there is anyone out there with perhaps similar genetic mutations, or someone who thinks they have a helpful suggestion of new things to try or a way forward from here. Thanks a lot!