I'm wondering if anyone knows things *other* than GH that can stimulate IGF-1? In a normal situation, a high level of GH would stimulate a high level of IGF-1 which would then follow a negative feedback loop and consequently decrease GH production. But if something else was stimulating the high IGF-1, then the GH level could remain low despite the high IGF-1. In this case, taking GH or a synthetic GHRH might have some benefit even with a high IGF-1. Any ideas what that *something* might be? It looks like cytokines may have some involvement too.