@Jonathan Edwards, do you think infusions of 500mg every 3 months is a wise choice in ME? If you had to pay out of your own pocket for off label treatment would you consider stretching this to 4 or 5 month intervals?
I've noticed that in their open phase 2 study they gave maintenance treatment after 3, 6, 9 and 15 months. In the new study they have swapped 15 out with 12. In the blinded phase 2 study the last maintenance dose was given at 12 months follow up.
Can we speculate whether it would be beneficial to delay infusions until a patient is experiencing relapse? Or wait 6 months rather than 3 after a year of infusions? That would be more cost effective, but since Rtx works quite slow it could lead to a total relapse, couldn't it?
I know the discussion is premature, but it is nevertheless interesting. At least for patients being treated in San Francisco. Infusions there aren't exactly cheap.