I am trying to work out what dose of the methylation supplements (Rich's SMP) my daughter should take as she prepares to start planning for a family? Both my daughter and I had ME severely 20 years ago. We both made a reasonable recovery; she was able to finish her studies and to go to work. She still has to be careful and organises her activities carefully. Sadly I have taken a prolonged dip and I am trying to get some success with the methylation protocol. Now in her thirties she is planning to start a family and we are concerned about epigenetic possibilities mentioned by Amy Yasko of passing problems on to the baby. What doses do people take who have restored their glutathione levels and achieved a reasonable level of fitness?