Dear friends, I am a new member of the forum. Thank you for those who administrate and support this forum and the help been given to so many people. I have been sick for about 6 years and now I spend 15-20 hours daily in bed. I'm on the process of finding a correct diagnose. In my case I have a consistent immunologic pattern of: Lymphocytes: High Neutrophil: Low Immunoglobulin E: Very high Doctors think this indicates a chronic viral infection and over active immune system. Let me please make some questions and listen to your opinion: Can I be immune depressed if my body still produces lymphocytes and immunoglobulin E which shows is reacting to something wrong? Can I be immune depressed and immune over active at the same time? Is it not the common pattern in CFS to have low lymphocytes instead? Thanks so much for you valuable opinion. Cheers!