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what is causing adverse reactions to SSRI class of drugs?

Discussion in 'Neurological/Neuro-sensory' started by justy, Jul 6, 2011.

  1. Nielk

    Nielk

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    You can add me to the list of people who were damaged from anti depressants. For the first year of being sick, my GP had me convinced that I was depressed. He said "you know sometimes we are depressed and don;t even know it-I'll put you on anti depressants and in a couple of weeks you will feel good as new" That little sentence started my slip sliding into an abyss that took me over two years to get off of. By that time, I was so sick with ME that the specialist I finally went to said that he can put me on his protocol but, he doubts it will help me because I should have come to him way earlier and before it became too severe. Of course, his protocol didn't help as many other treatments.
     
  2. Enid

    Enid Senior Member

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    All drugs have side effects according to my Bro (Neurologist) they just have not got it right for ME simply because most Docs are still learning.
     
  3. justy

    justy Senior Member

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    Im sure more and more that Rich's Methylation block Hypotheses plays a major part in all of this. My reaction to Citalopram was so severe and on such a small dose, it can only be because my system is not dealing with the drug properly and so it builds up leading to a mild serotonin syndrome which ios often undiagnosed or else the reaction is used to "prove" that you have an anxiety or other mental health disorder. It took me 2 years to recover from 2 doses of Citalopram and my GP just seemed to think this proved i was "mentally ill" Since having a proper M.E diagnosis and the effects of the Citalopram wearing off i have never had such "good" mental health with virtually no anxierty since i learned to pace and rest.
     
  4. Tristen

    Tristen Senior Member

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    Same here, only it was 4 years of taking every anti-depressant known, every single one of them making me more ill. Add that to the inability to be properly diagnosed and continuing to "push through it", the disease progressed. Being limited within a community that knew nothing of me/cfs, I had to chase down the diagnosis myself. By the time the CCC came out and I knew for sure what I had and what needed to be done, I was bed bound severe, with minimal chances of recovery. Had I known in the beginning what I know now, I could have prevented disease progression. May even have fully recovered.

    Anyhow, I have a far worse reaction to anti-depressants than any other medication. If I take any of them, I will get a rush of feeling better for 1-2 days, then crash into what feels like holding both the gas and the brake hard to the floor. Then it will put me in bed with severe symptoms. I get the same reaction irregardless of dose. I eventually realized that I wasn't dealing with depression, but some kind of neuroimmune disease.

    It is what it is, I have climbed back from severe levels, and do believe that major recovery is possible. Wouldn't experience windows of wellness otherwise. But my reaction to anti-depressants is well beyond being just a "sensitivity", it's more like being poisoned.
     
    Webdog likes this.
  5. justy

    justy Senior Member

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    Tristen, your experience is so similar to mine. I am so sorry you have had to go through this but i am glad you have posted your experience (and yours Neilk) as we can feel stronger together.

    Justy x
     
  6. Tristen

    Tristen Senior Member

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    Thanks Justy, I needed that today
     
    MEMum likes this.
  7. Nielk

    Nielk

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    "Do not stand by while your neighbor's blood is shed" -Leviticus 19:16

    How do we know that if one sees someone drowning, being mauled by beasts, or being attacked by robbers, one is obligated to save him?n From the verse, "Do not stand by while your neighbor's blood is shed."
    -Babylonian Talmud, Sanhedrin 73a (Talmud is the compilation of Jewish oral laws)

    I hold the CDC, HHS, AMA responsible for all the horrors that we are going through. They know what's going on and they choose to close their eyes to it. They choose to ignore us or even worse they malinger us by trying to make it seem that we have a psychiatric problem when they know very well that we have a severe organic condition. they choose not to inform medical students or any medical doctors the truth about this condition.
    The fact that the CDC has refused to make any changes on their website, to me is the same as if they shot an killed the PWCs who have died from this disease.
     
    Paralee likes this.
  8. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    i think even though ssri's are selective of serotonin they still act on noradrenaline as well but to a much lesser degree. I think alot of us who have sleep issues, anxiety even adrenal hormone issue produce too much noradrenaline to compensate for low cortisol etc. This noradrenaline thats making us feel tired but wired and using these meds increases the wired part and this is what makes us feel sick etc. Its interesting that i have not had any bad reactions from supplements of 5htp of tryptophan even with large doses, maybe because it only effects serotonin, no effect on noradrenaline. A pity doctors dont measure serotonin and noradrenaline before dishing out antidepressants, i think antidepressants are there go to medication when they dont know whats going on, which i think can be dangerous. Early in my time with cfs i could tolerate very low doses of zoloft, it all it really did was make me feel better about feeling like crap, if that makes sense, didnt really help with energy concentration etc. For the right people i think they can be useful but doctors a guessing who they will work for.

    cheers!!!
     
    WillowJ likes this.
  9. alex3619

    alex3619 Senior Member

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    There is some old European research (I dont have a handy reference, I think it might have been Swedish) that shows we have normal or low serotonin, but increased numbers of a particular type of serotonin receptor (I don't recall which receptor type)/. Bye, Alex
     
  10. Ocean

    Ocean Senior Member

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    I really don't know the politics surrounding all that. Can anyone give just a very brief and easy to understand explanation as to what the CDC et al stands to gain by knowingly misclassifying the illness. I've heard many make similar comments but cannot understand what the motive behind it would be.
     
  11. Carola

    Carola

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    Nobody could have been more surprised than I was that I developed serotonin syndrome (clinical diagnosis totally solid), given the tiny dose I was on. I had been hesitant to start an antidepressant but reckoned that nothing bad could possibly happen. The other drug I take is ketotifen, an antihistamine (H-1 blocker), so I thought if anything there would be sedating effects. But no, on the contrary.

    I learned that amitriptyline can have a half-life ranging from 8-50 hours - and I'm guessing that I'm on the longer end of the spectrum. Four days after stopping the drug I'm still having tremor and tachycardia.
     
  12. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Supposedly covering up past failures like the cfs outbreaks in the mid 1980s. If they classify this as an immune/infectious disorder they are owning up to their initial mismanagement of the situation from the 1980s. these outbreaks were classed as mass hysteria and never investigated properly. A good book on all of this is Oslers web, but reading it is frustrating as u slowly find out the truth. if they were on the ball back then we would probably have alot more effective treatments and doctors would believe this is a real illness.

    cheers!!!
     
    WillowJ likes this.
  13. Ocean

    Ocean Senior Member

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    Thanks a lot Heapsreal, makes sense.
     
  14. justy

    justy Senior Member

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    My doctor told me the citalopram would be out of my system within 2 days or "you'll be fine by the end of the weekend" It took two years of literal hell before i started to recover from the effects of this drug.
     
  15. Nielk

    Nielk

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    Besides the need to cover up their past mistakes, the insurance industry lobby has all these government agencies in their pockets. If ME/CFS were to be labeled as they should be according to the new ICC, the insurance companies are afraid of all the claims, drugs, tests, disability they would have to pay out. It always boils down to MONEY!
     
    ahimsa likes this.
  16. endomeister

    endomeister

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    If you are an overmethylator (not saying you are) then your experience would make sense. Also, are you aware that a possible side effect of some antihistamines (including Ketotifen) is tachycardia?

    Both meds that elevate serotonin (like SSRI's, etc.) and antihistamines may not be a good idea if you are in fact overmethylating.
     
  17. Ocean

    Ocean Senior Member

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    I can't remember if I replied to the main content of this post or not. I too can't tolerate antidepressants. If it had to do with seratonin, I definitely wouldn't be surprised.
     
  18. wdtony

    wdtony

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    I had a severe adverse reaction to one 10mg pill of escitalopram in 2006. It took 2.5 years to feel human again. I continued to improve over the course of 3.5 years but never returned completely to normal or to full time work. At 3.5 years post reaction I suffered an ischenic stroke at age 38 and awoke half paralyzed. That was in 2010. No cause was found and after extensive testing I had no risk factors or causal factors for stroke. I am at 10 years post reaction now and still suffer from amplified sensitivity to many stimuli. I am terribly sensitive to any drug that crosses the blood brain barrier. I am in need of 2 surgeries and cannot tolerate anesthesia or pain medication. The SSRI has ruined my life. I live in fear of needing minor surgery.
     
    justy likes this.
  19. GreyOwl

    GreyOwl Dx: strong belief system, avoidance, hypervigilant

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    Hi @wdtony. Welcome to PR! There is an Introduction forum you might like to visit so that more people will read your post.

    @alex3619, if you have this research available I would be very interested in reading it (I know you wrote your post in 2011!). My theory is not that ME is increased receptor numbers, but hypersensitive/dysfunctional receptors which is where I think research is heading now. Hypersensitive and dysfunctional receptors explains reactions to many drugs, including some antihistamines:
    Cocaine-like neurochemical effects of antihistaminic medications
    Tanda G, Kopajtic TA, Katz JL.
    J Neurochem. 2008 Jul;106(1):147-57. doi: 10.1111/j.1471-4159.2008.05361.x. Epub 2008 Jul 1.
     
  20. frog_in_the_fog

    frog_in_the_fog

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