What if CFS/ME (hate to throw these together so forgive me if it offends people) is an autoimmune condition? There are so many different autoimmune conditions that attack different parts of the body; the stomach with crohns, the thyroid with hashimotos, the joints with arthritis etc Recent research has even shown that alopecia is an auotimmine condition in which the immune system attacks the hair follicles and they are now saying fibro is autoimmune. A lot of people develop autoimmune conditions after virus, accidents, injections, pathogens etc. It would explain why rituximab and LDN work for a subsection of CFS/ME patients and why there are so many family members with similar conditions. I also read that OCD and autism could be an autoimmune disease in which the brain is targeted by the immune system. Not that it helps any of us but it would explain a great deal.