Men produce a certain amount of progesterone and in both sexes helps balance estrogen. Progesterone has activity on gaba receptors, supposedly improves gaba sensitivity. My experience was with a progesterone cream from iherb and was experimenting with it to help sleep. Testing has shown my progesterone is below normal, this can also be a sign of low cortisol too as hormones tend to flow from progesterone to cortisol. The first night i used it, it floored me and sleeped well and woke with a hangover, felt really drugged. I think it worked for a couple of nights then stopped working. I have tried it intermittently and havent been able to repeat the effects. As a treatment for sleep in guys, i havent read about too many successful stories, but im sure its helped some guys.