I made a thread recently asking for supplement recommendations and listed some of the stuff I've tried -- which covers most mainstay supplements, like B12, Vit D etc. My 'adrenal fatigue' is really bad, and I can crash from very minor stressors like noise etc. (which are plentiful at home). However, I am also finding that I can't tolerate anything anymore, and that previously useful supplements don't help the way they used to. The only things that have provided some relief have been the Ayurvedic herb Haritaki (which I can't stay on because it kills E.Coli), and Vitamin C before bed. Symbioflor 2 was also good, but less helpful the last time I tried it. The Vitamin C (time release, 3-5g) was really working for about 4 weeks and I could tolerate a lot more stressors. But now all it does is put me to sleep, with no residual benefits the next day and I can barely tolerate a cup of coffee. So what happens? My baseline state is one where I'm assaulted by inflammation, adrenaline etc. and all the horrible symptoms of 'low cortisol' like feeling extremely overwhelmed and anxious. But it doesn't seem I can take anything to help either. I ordered some glutathione to try, but don't know if I'll tolerate it either. Other than that, all I have are other herbs like Oregano etc. but it doesn't seem like my body can handle the die-off they produce.