Discussion in 'General ME/CFS Discussion' started by pizzahead, Mar 21, 2016.
Does this impact mood, digestion or both?
I have heard that serotonin increases gut motility, but I don´t know about dopamine.
Serotonin increases gut motility. There are pro-motility drugs that stimulate 5HT4 receptors, such as prucalopride.
Dopamine decreases gut motility, since dopamine antagonizes acetylcholine, which is the main neurotransmitter in the digestive system. There are pro-motility drugs that block dopamine, which increases acetylcholine concentrations, such as domperidone.
Regarding mood, there is no direct connection with serotonin levels in the brain and serotonin in the intestines. The classic example is eating a banana - contains lots of serotonin - but bananas don't cure depression, let alone influence brain serotonin levels.
You also have to understand that most with ME/CFS have altered gut flora resulting in access levels of free radicals in the system.
This then results in deficits and conversion issues of vitamins, minerals and amino acids into critical neurotramsmitters ie. Serotonin which is involved in 3000 bodily process if memory serves me correctly.
LPS at high levels in the blood stream is directly correlated to conversion issue of L Tryptophan into Serotonin again if my memory serves me correctly.
I'd always assumed that it was the "serotonin" effect that caused gut issues for me when I took antidepressants.
My stomach grew painful, distended and mobility seemed to stop altogether.
(p.s. I was not suffering from depression. The AD trial was supposed to help with pain and sleep but didn't)
Not sure why this happened. Just mentioning in case it is useful.
Was it the chicken or the egg....tough to know
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