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What exactly does it mean when something is a MAO inhibitor ?

Discussion in 'Genetic Testing and SNPs' started by juniemarie, May 16, 2015.

  1. juniemarie

    juniemarie Senior Member

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    Albuquerque
    Something is making me so sleepy, can barely keep my eyes open even after taking Adderall, No-Doz and a cup of coffee.

    3 weeks ago I began taking Rhodiola and I just read it was a an MAO inhibitor.

    I am MAO +/+

    Could it have anything to do with the sleepiness? I know its an adaptogen which I thought would decrease fatigue, but theres more to these adaptogens than I thought…..as far as how they interact with the body chemistry.

    Sometimes things that make others awake and jittery have the exact opposite effect on me
     
    belize44, Sushi and helen1 like this.
  2. ppodhajski

    ppodhajski

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    Chapel Hill, NC
    Are you homozygous for MAOB as well?

    MAOI's inbit the the MAO enzyme from breaking down catecholamines like serotonin, dopamine, norepinepherine.
    http://img.medscape.com/slide/migrated/editorial/cmecircle/2007/6769/images/mod1/slide37.jpg

    MAOA preferentially degrades serotonin. I am making the assumption that Rhodiola preferentially inhibits MAOA.
    http://www.ncbi.nlm.nih.gov/pubmed/19168123

    My other assumption is that your MAOB genes are fine since you would probably have had greater anxiety taking Rhodiola.

    The More serotonin you have hanging around the more it will turn into melatonin which might make you sleepy.
    http://www.pharmacorama.com/en/Sections/images/Serotonin_2_clip_image004_0000.gif

    MAOB is the back up degrading enzyme for Serotonin.
     
  3. juniemarie

    juniemarie Senior Member

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    Albuquerque
    @ppodhajski That is very interesting I will have to investigate further and see if it leads to any insights
     
  4. juniemarie

    juniemarie Senior Member

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    Is @ppodhajski still around? Wanted to pick his/her brain some more about this serotonin MAO subject…..was unable to send a PM either
     
  5. belize44

    belize44 Senior Member

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    I have just found this thread and wanted to reply that since starting to take Rhodiola, I have felt like I was in a severe crash for going on ten days now.
     
  6. Paralee

    Paralee Senior Member

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    I can't take Rhodiola for some reason, but as a last thing to try when I needed something I would take some St. John's Wort. I have read it has MAO properties of some type, but I haven't used it in years, because it also can raise blood pressure in some people.
     
  7. belize44

    belize44 Senior Member

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    Since I wrote that last post, I have swung to the opposite extreme. I started feeling really wide awake, and then found it difficult to fall asleep!:confused:
     

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