Oh, ok. I forgot I said that. I didn't realize too much folate could cause problems for cancer. I usually thought of methylation as good due to possible lowering of homocysteine. I know one person who is COMT ++ and is taking a high amount of methylcobalamin due to B12 deficiency symptoms and she was having problems with even a small amount of folinic acid. Everyone's different, but it's possible you could have the same issues. The reason Rich recommends folinic acid is for nucleotides which are used for creating RNA and DNA and also making ATP. At higher doses, dbkita said folinic acid is for CNS penetration and saturation just as the high doses of methylfolate is used for by some people here. I asked him if that was the same thing as neurological healing and he said yes. I think I have more questions about that, but I'll ask you later in a private conversation because I don't wan to tie up this thread anymore and also because I've asked you a lot of questions already.