Hi guys. I've had high active vitamin b12 now for a few years and I have no idea what it means or why it's occurring. I have the MTHFR mutation (homozygous) and my practitioner wants me to take high doses of B12 but I'm concerned that I'm not breaking it down or utilising it properly. Does anyone have any insight? I've heard it could be related to a COMT mutation but I have no idea what that is. Any help would be greatly appreciated, thank you.