This is a brief history of my experience with testosterone. 2002: Took injectable 225-350mg per week for 5 weeks for body building purposes. Had a typical reaction that any bodybuilder would have to it. Gained muscle, no negative effect on mood other than agression. It may have increased my blood pressure as I recall feeling a little spacey after a theme park ride. Also towards the end of the cycle i noticed some prostate pain with urinating(this went away immediately post cycle) 2003: Took xanax for 1 year, developed tolerence, side effects and withdrawal. This was the start of my chronic fatigue. 2005: After testing low on Free T but normal total T, endo prescribed testosterone. I injected 125mg and experienced severe depression/anxiety not long after the shot and the feelings lasted a week. I felt like I was in hell. I put it down to after effects of benzo withdrawal. Yesterday: Now total T is on the low wend of range so GP gave me testogel samples. I took a 50mg satchet(yielding approx 5mg of testosterone). No immediate feelings but started feeling worse several hours later and today felt terrible. Anxiety, depression, spaced out. I actually didnt think it was from the testogel since it was just one dose of a small amount(i thought it was more likely the amoxcillin i stopped taking a couple of days ago for a dental infection) but i found other people who have had a similar reaction from one or a few doses of testogel. See this thread: http://www.allthingsmale.com/community/threads/anxiety-from-androgel.4573/ I cant help but feel whatever testosterone is doing I need it to do the opposite to improve. Some of the theories on that thread suggested it might be converting to estrogen or it might be suppressing cortisol. Adrenal fatigue?