Guidelines about what constitutes reliable evidence are not the same as the NICE guidelines. I think you can trust the information related to reliability re: anecdotal evidence versus controlled studies etc. If you look at the NICE guidelines related to CFS, you can discern that it is not based on reliable evidence (Pacing and GET). I agree with the following post. Maybe read the thread and apply some logic to your posts rather than just disagreeing without thinking through what you are saying. You asked what constitutes reliable evidence, you have been give some really good answers and I believe you have been provided a good basis for understanding. You just seem to want to twist words and argue so I am out too.