Hi. Lately, my biggest problem with ME are the symptoms that arise after waking up. I'm talking about raised heart rate immediately after waking up, before even standing up, dizziness, feeling lightheaded, muscle weakness, shortness of breath, and difficulty thinking. The severity of the symptoms seems to increase the longer the sleeping time is, for example they are worse if I sleep a 1 hour nap than if I sleep a 2 hs nap, and in the morning after sleeping 7/8 hours they are much much better. This symptoms progressively improve as the time after waking passes, until they get to a minimum after two ours (I've got some form of some of those symptoms at other moments of my day). I was surprised to read a very precise description of this on a text which a user of this forum referred me to, which I think is from a trustworthy source (Open Medicine Foundation). http://www.openmedicinefoundation.org/what-is-mecfs/
The interesting part of the text reads as follows: "But it also has other symptoms, such as waking up feeling drained or like you have a hangover. Most of these patients take more time (up to two hours) to transition from sleeping to awake activity"
Another piece of information I can share is that I take Clomipramine; and despite it is clearly not what causes the symptoms as I had them before taking it or taking any other medication, I clearly worsens them. I consider that taking in account the physiological changes that this med causes could shed some light on what the causes of the symptoms are. According to Wikipedia, which cites various sources "Clomipramine is a highly selective (~200x over norepinephrine) inhibitor of serotonin reuptake.[31] It is also an antagonist/inverse agonist at the histamine H1 receptor, the muscarinic acetylcholine receptors and the α1adrenergic receptor.[31] These last three actions likely contributes to its adverse effects.[31]"
My questions to you are the following:
The interesting part of the text reads as follows: "But it also has other symptoms, such as waking up feeling drained or like you have a hangover. Most of these patients take more time (up to two hours) to transition from sleeping to awake activity"
Another piece of information I can share is that I take Clomipramine; and despite it is clearly not what causes the symptoms as I had them before taking it or taking any other medication, I clearly worsens them. I consider that taking in account the physiological changes that this med causes could shed some light on what the causes of the symptoms are. According to Wikipedia, which cites various sources "Clomipramine is a highly selective (~200x over norepinephrine) inhibitor of serotonin reuptake.[31] It is also an antagonist/inverse agonist at the histamine H1 receptor, the muscarinic acetylcholine receptors and the α1adrenergic receptor.[31] These last three actions likely contributes to its adverse effects.[31]"
My questions to you are the following:
- do you experience this situation? what are the details?
- are your "after awakening symptoms" related to the amount of time you sleep before waking up?
- anybody has any information regarding the physiological causes of this "after waking up" symptoms and/or any text related to the issue?