Earlier this year I tried to cut back to the supplements I was feeling the most benefit from, namely B2 and K2. I gradually phased out other things and also got sent a higher dose of B2 than I wanted, but took it anyway (50mg, 3-4 times per day) and was taking up to 45mg of K2 split across the day. When I tried to reintroduce other minerals I had lost all tolerance for them; couldn't even titrate up from crumbs. Recently I tried a mineral supplement that contained 3mg of boron, and suddenly I was able to tolerate the other minerals with virtually no problems... I have read B2 and boron can deplete one another. This boron supplement has been sat in my cupboard for months and I was too scared to try it! Things aren't quite fixed yet, but I feel like I'm on to something. I have been taking a fancy B complex, so hopefully that is covered. Does anyone know what other vitamins and minerals might be depleted by too-high doses of B2 or K2? Thanks!