Hello everyone, I am MTHFR C677T homozygous. Every time I try to take a methyl donor like L-methylfolate or trimethylglycine (TMG) I get anxiety, and I am trying to find out what could be the cause. These are the results from 23andme: COMT V158M rs4680 GG -/- VDR Taq rs731236 AA +/+ MAO A R297R rs6323 GT +/- MTHFR C677T rs1801133 AA +/+ MTRR A66G rs1801394 AG +/- MTRR K350A rs162036 AG +/- MTRR A664A rs1802059 AG +/- I went to see my naturopatic Doctor today, and She told me my symptoms do not match with the results from the test, meaning people who are COMT V158M rs4680 (GG) (-/-) should tolerate the methyl donors well. She does not understand why I get anxious when I take a methyl donor. Do you have any ideas why this could be happening ? BTW, I take pristiq - 150 mg. Thanks a lot for your help.