Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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What can C4A indicate?

Discussion in 'Addressing Biotoxin, Chemical & Food Sensitivities' started by skyfall, Feb 1, 2017.

  1. skyfall

    skyfall

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    My recent labs showed:

    C4a: 9695
    C3a: 174
    VEFG below 31 (Didn't specify range)
    TGFB1: 4120
    HLA genes showed mold susceptible
    MM9: 738
    ADH: <8

    I test negative for lyme on regular lyme tests, positive on igenex, negative on nano trap, and one strain on DNA connexions. Bart was negative and babesia.

    Can c4a point towards anything other than mold? I am really confused because I just don't know what it is and what to address first. My doctor wants to treat mold but I can't even handle 2 pills without feeling terrible and I am supposed to work up to 6.

    Also, can welchol or cam deplete nutrients and minerals?
     
  2. *GG*

    *GG* Senior Member

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    Concord, NH
    2 pills of what? My Dr treated my detox via cholestyramine (CSM) and chlorella.

    GG
     
  3. skyfall

    skyfall

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    2 pills of welchol.
     
  4. fromstrawtomore

    fromstrawtomore

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    Brisbane, Australia
    C4a can indicate other inflammatory conditions (search PubMed and SelfHacked) but when combined with high TGFb1, positive HLA, low VEGF, low ADH and high MMP9 it strongly indicates CIRS. Whether this is CIRS-WDB (mold) or CIRS Lyme, or both can't be determined from those results.

    Have you tested your home via ERMI?

    Welchol is less likely to reduce vitamins/minerals compared to Cholestryamine but probably best to supplement with A, D, E, K, Co Q10 if not already.
     
    Forebearance likes this.
  5. fireflymd

    fireflymd

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    From my own experience I recommend you contact the lab center that drew your blood, to be sure your C4A was processed correctly.

    The lab has to spin down the sample within a half hour of drawing your blood and then freeze it; it must then be shipped on dry ice to the specialty lab, National Jewish.

    If they do not spin it down within half an hour and freeze it, and if they do not ship it out on dry ice, you may get a falsely elevated level. The longer it takes them to spin down the blood and freeze it, the higher the level becomes.

    Some labs do not even keep dry ice at the drawing center, so the longer the blood is left unfrozen, the level will be turn out grossly inaccurate--falsely elevated. The dry ice keeps the sample frozen until it can be tested.

    Since discovering the lab drawing center that took my blood did not have dry ice available when they sent my blood to the main lab resulting in a falsely elevated C4A, I think it's important to check for oneself. When it was repeated and done properly, my level was over 11,000 points lower, and I had not changed or done anything.

    This enormous "decrease" would have led me to believe something was working, when in fact, I had not started any treatment. This was so discouraging to me, but I think it's important to know this test can really be screwed up so that you wind up with very high levels which may not be accurate.

    My integrative doc insisted the elevated C4A means Lyme, but I have read it can mean mold biotoxins as well.

    This was the only other thing I could find:

    https://www.aaaai.org/ask-the-expert/c4a-complement-component
     
    Last edited: Mar 19, 2017

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