The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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What are seminal studies in ME research?

Discussion in 'Latest ME/CFS Research' started by JaimeS, Jul 11, 2017.

  1. Alvin2

    Alvin2 If humans were rational...

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    Don't forget the metabolomics study from Dr Naviaux
     
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  2. denmarkk

    denmarkk

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    Staines and Marshall-Gradisnik
    Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217865/
     
  3. Hip

    Hip Senior Member

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    I don't think any seminal list of studies could miss the grandaddy of all ME/CFS causal theories: namely the enterovirus theory. There is a list here of many of the papers finding high levels of enterovirus in ME/CFS patients' blood, muscles, brains and stomachs.
     
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  4. Forbin

    Forbin Senior Member

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    I guess this would be considered seminal...

    About four years ago, I found the original, 90 page Public Health Service report on the 1934 Los Angeles outbreak in the online archives of the University of Michigan. With some difficulty, you could only access a page at a time at that website, so @Valentijn took the time to download it, page by page, and compile it into a .pdf, which @wdb was able to put on the PR website here:

    http://phoenixrising.me/wp-content/uploads/LA-outbreak.pdf

    It's written in the context of the time, when the major concern was a fairly limited outbreak of polio in Los Angeles. They knew something else was afflicting the staff of the hospital, however, so the author tried to document it. Later, in the 1950's, the outbreak in Los Angeles was regarded as similar to other outbreaks which had occurred in the 50's, principally the one at Royal Free Hospital in 1955.
     
    Last edited: Jul 13, 2017
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  5. Countrygirl

    Countrygirl Senior Member

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    It is our very own The God of Pleasure who compiled it.
     
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  6. slysaint

    slysaint Senior Member

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  7. Jenny TipsforME

    Jenny TipsforME Senior Member

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    What about seminal studies on the horizon? Do we think the rituximab trial will be seminal? Feeling optimistic?

    Sorry @JaimeS a bit :p we're on the lookout for upcoming biomedical trials NICE should be in eager anticipation of!
     
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  8. Jenny TipsforME

    Jenny TipsforME Senior Member

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    What about gut studies? Are any considered seminal? The Hanson one?
     
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  9. RogerBlack

    RogerBlack Senior Member

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    Unless there is little to no effect, absolutely.
    The rituximab trial is a double-blinded trial.

    In principle, the Rituximab phase II trial could have been the most effective and powerful placebo trial ever conducted in CFS.
    it was not blinded, and arguments could be made that this could also indicate that the response was a massive placebo response, and consistent with CBT results. (though much, much more effective).

    The phase III trial doesn't suffer from this.

    The patient doesn't know which treatment they're getting, it's a largish trial, and the response measures are allegedly significantly larger than have been seen by CBT.

    This tells us:
    It is not psychological, because there is no psychological component of the treatment.
    It is not 'benefit seeking', as otherwise there would be no effect.
    It is one disease that can be reliably selected by clinical criteria without need for a blood test.
    There is hope for a treatment - even if rituximab isn't it for some reason.
    Other treatment with tiny effect sized and moderate to considerable costs (CBT, ...) is much less effective. (arguably not effective, but that's a seperate argument).

    If the effects are 'significant' (much larger than 1/7 patients more in the trial arm report 'better, or very much better at 12 weeks), or much better than 5-7% improvement by a tiny amount (GETSET and PACE 12months paper), we can almost stop hammering on those trials, as they are so ridiculously outclassed.

    (of course, we absolutely should not stop hammering on these trials until at the least significant errors in the methodology are addressed through retraction, letters of concern by journal editors, or the global understanding in every nation that these are not useful approaches)
     
    Last edited: Jul 14, 2017
  10. JaimeS

    JaimeS Senior Member

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    Definitely!
     
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  11. JaimeS

    JaimeS Senior Member

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    Thanks so much to everyone who's responded so far! I'm going to have to winnow, some, so my readers don't get overwhelmed, but I really appreciate your help. :hug:
     
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  12. Alvin2

    Alvin2 If humans were rational...

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    Who is this for btw?
     
  13. JaimeS

    JaimeS Senior Member

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    It's to put on Stanford's CFS wiki as a general reference for any researcher who wants to look. :)
     
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  14. Alvin2

    Alvin2 If humans were rational...

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    Very interesting, can you link it here when done :)
     
  15. JaimeS

    JaimeS Senior Member

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    I'll make a blog post on it and post it here as well, absolutely
     
  16. Alvin2

    Alvin2 If humans were rational...

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  17. JaimeS

    JaimeS Senior Member

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  18. Alvin2

    Alvin2 If humans were rational...

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    I imagine this whole project is quite the undertaking
     
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  19. JaimeS

    JaimeS Senior Member

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    Which is part of why I love my knowledgeable community so very much! Thanks again to everyone who has helped out!
     
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  20. cigana

    cigana Senior Member

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    Schutzer's study is my favourite. Clearly distinguishes CFS from healthy controls and chronic Lyme, and gives a plethora of potential biomarkers.
     
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