The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
Discuss the article on the Forums.

What are seminal studies in ME research?

Discussion in 'Latest ME/CFS Research' started by JaimeS, Jul 11, 2017.

  1. JaimeS

    JaimeS Senior Member

    Messages:
    2,905
    Likes:
    10,042
    Mid-Ohio Valley, United States
    Hello, all! I am curating a small collection of the best / most interesting ME/CFS studies to make an informative packet regarding what we know about ME/CFS. Each will have a small commentary, so consider poorly-performed studies that have had an impact on the ME/CFS landscape, such as PACE.

    From the quick article / intro to ME/CFS I wrote as a blog post awhile back:

    FLUGE AND MELLA 2016; ARMSTRONG ET AL, 2016; ARMSTRONG ET Al, 2015

    Recent research from Fluge and Mella in Norway, and Christopher Armstrong of Australia have identified errors in cellular energy metabolism in ME patients that differs from sedentary controls. Reduced glyolysis, accompanying high blood glucose, and metabolites that demonstrate a marked uptick in mitochondrial activity in response have been documented. Other energy-producing reactions’ metabolites were elevated, which may indicate compensatory energy metabolic mechanisms in people with ME. Women’s amino acid stores in particular are being utilized in place of glucose, and are decreased in comparison to that of healthy controls. Women’s diet showed no difference in protein intake than in controls.

    Further analysis by Fluge and Mella impicated PDH inhibitors as a mechanism for decreased glycolysis.

    Finally, bathing culture-grown cells in ME patients’ serum caused them to exhibit the same metabolic abormalities as patients’ cells.

    HANSEN ET AL., 2016

    Hansen of Cornell as well as researchers from the University of Melbourne have confirmed an older study’s results showing that ME patients have gut bacteria that is not just different from controls, but different in a predictable manner, with Firmicutes and Bacterioides off. Using a machine-learning approach, the Melbourne team was able to identify the right patient utilizing a sample of their gut bacteria over 80% of the time.

    HORNIG ET AL, 2015:

    Mady Hornig and her team at Columbia University discovered a pattern of upregulated inflammatory and anti-inflammatory markers in early ME (first three years after onset) all of which were inverted in late ME (over three years after onset). Long-term patients’ immune markers were lower even than those of controls.

    Dysregulated immune markers included IL-12p40, IL-12p70, IFN-gamma, TNF-alpha, and GM-CSF (CSF2). The marked involvement of interferon-gamma points to an initial infective trigger, as it is the product of activated T-cells, natural killer cells, and macrophages.

    Hornig’s study, besides pointing to a future blood test for ME, is the first to identify a two-stage illness, with an acute phase and a chronic phase.

    NEWTON ET AL, 2015:

    Julie Newton and her team discovered that muscle cells of patients with ME had increased myogenin expression but decreased IL-6 secretion in comparison to controls and, when an electrical pulse was sent through the tissue to simulate exercise, muscle cells of ME patients demonstrated impaired AMPK activation and impaired uptake of glucose. Cells responded normally to insulin.

    FLUGE AND MELLA:

    Fluge and Mella found that the anti-cancer drug Rituximab caused complete remission in a significant percentage of ME patients.

    Other suggestions?

    [Edit: changed first Fluge and Mella citation to 2016 -- it came out in December of 2016. I had it as a 2017 article.]
     
    Last edited: Jul 23, 2017 at 12:30 PM
    concepcion, rosie26, Webdog and 21 others like this.
  2. A.B.

    A.B. Senior Member

    Messages:
    3,228
    Likes:
    18,755
    Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial
    http://www.tandfonline.com/doi/abs/10.1080/21641846.2017.1259724?journalCode=rftg20

    Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness
    http://iom.nationalacademies.org/Reports/2015/ME-CFS.aspx

    A community-based study of chronic fatigue syndrome.
    I believe this was the first large random sample population study which showed that many patients were undiagnosed, it wasn't a white middle class woman's illness, and that about 0.4% of the population had it.
    https://www.ncbi.nlm.nih.gov/pubmed/10527290
     
    Forbin, Demepivo, Mary and 4 others like this.
  3. Wonkmonk

    Wonkmonk

    Messages:
    60
    Likes:
    70
    Germany
    Barry53 and JaimeS like this.
  4. JaimeS

    JaimeS Senior Member

    Messages:
    2,905
    Likes:
    10,042
    Mid-Ohio Valley, United States
    Thanks @A.B. -- for sure, if we include a single community-based study it should be that Jason one.

    IOM is so huge, but we should probably have that, along with the CCC.
     
    Barry53 likes this.
  5. JaimeS

    JaimeS Senior Member

    Messages:
    2,905
    Likes:
    10,042
    Mid-Ohio Valley, United States
    Barry53 likes this.
  6. Jenny TipsforME

    Jenny TipsforME Senior Member

    Messages:
    936
    Likes:
    2,880
    Bristol
    Bookmarked this thread :) too tired right to think of additions

    Although what about

    1: Light AR, White AT, Hughen RW, Light KC. Moderate exercise increases
    expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome
    patients but not in normal subjects. J Pain. 2009 Oct;10(10):1099-112. doi:
    10.1016/j.jpain.2009.06.003. Epub 2009 Jul 31. PubMed PMID: 19647494; PubMed
    Central PMCID: PMC2757484.

    I think the 2009 one is what I'm thinking of
     
    Last edited: Jul 11, 2017
    Forbin, wigglethemouse, Hutan and 3 others like this.
  7. Snowdrop

    Snowdrop Vexacious, thy name is PACE

    Messages:
    2,526
    Likes:
    7,710
    Toronto
    Forbin, Webdog, Mark and 3 others like this.
  8. Wonkmonk

    Wonkmonk

    Messages:
    60
    Likes:
    70
    Germany
    This is very interesting. I have dry and red eyes for several years now and it only occurred recently to me that it might be part of CFS. It always got worse with Vitamin D and/or calcium supplements over several weeks, so I suspect there might be connection as well.
     
    Snowdrop and JaimeS like this.
  9. JaimeS

    JaimeS Senior Member

    Messages:
    2,905
    Likes:
    10,042
    Mid-Ohio Valley, United States
    Yes, absolutely!
     
    Snowdrop likes this.
  10. lnester7

    lnester7 Seven

    Messages:
    2,197
    Likes:
    2,985
    USA
    Did they tested you for Sonjern syndrome? The right way with biopsy!
     
  11. ScottTriGuy

    ScottTriGuy Stop the harm. Start the research and treatment.

    Messages:
    986
    Likes:
    3,838
    Toronto, Canada
  12. JaimeS

    JaimeS Senior Member

    Messages:
    2,905
    Likes:
    10,042
    Mid-Ohio Valley, United States
    ScottTriGuy likes this.
  13. Wonkmonk

    Wonkmonk

    Messages:
    60
    Likes:
    70
    Germany
    @lnester7 I never heard of Sonjern Syndrome, but it sounds similar to Sjögren Syndrome, which was tested in a blood test (came back negative).
     
  14. dreampop

    dreampop Senior Member

    Messages:
    128
    Likes:
    329
  15. denmarkk

    denmarkk

    Messages:
    46
    Likes:
    141
    Maryland, USA
    So many from Leonard Jason. Too many to pick from, but here's three that stand out to me.

    A Prospective Study of Infectious Mononucleosis in College Students
    https://www.researchgate.net/public..._Infectious_Mononucleosis_in_college_students

    Estimating the disease burden of ME/CFS in the United States and its relation to research funding https://oatext.com/Estimating-the-d...ates-and-its-relation-to-research-funding.php

    Mortality in patients with myalgic encephalomyelitis and chronic fatigue syndrome
    http://www.tandfonline.com/doi/abs/10.1080/21641846.2016.1236588?journalCode=rftg20

    Good luck with your project!
     
  16. Mary

    Mary Senior Member

    Messages:
    2,399
    Likes:
    4,792
    Southern California
    MEMum, arewenearlythereyet and JaimeS like this.
  17. ScottTriGuy

    ScottTriGuy Stop the harm. Start the research and treatment.

    Messages:
    986
    Likes:
    3,838
    Toronto, Canada
    Not a chance - I was pointed to it yesterday by another Millions Missing Canada volunteer - so I'm not sure who, other than 'anonymous user' compiles and keeps it updated - but bless their soul.
     
    Jenny TipsforME, MEMum, AdamS and 4 others like this.
  18. Helen

    Helen Senior Member

    Messages:
    1,920
    Likes:
    2,868
  19. BruceInOz

    BruceInOz Senior Member

    Messages:
    161
    Likes:
    883
    Tasmania
    Has anyone mentioned the two day CPET?
     
  20. A.B.

    A.B. Senior Member

    Messages:
    3,228
    Likes:
    18,755
    This is important, but I'm not sure which studies could be called seminal.
     
    MEMum likes this.

See more popular forum discussions.

Share This Page