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What about the other B vitamins with methylation?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by minkeygirl, Jan 7, 2015.

  1. minkeygirl

    minkeygirl But I Look So Good.

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    I want to start methylation again. Can someone explain to me, really dumbed down please, how the other B's come into play?

    Because of crap adrenals I currently take 500 mgs B5 and I want to add B6 in the mornings. I can't take multi's because the smell gags me. I just want to start with these 2.

    All I need to know is if it's ok to take these with methylation.

    And did I say dumb it down? Like for a 2nd grader please! :)
     
  2. PeterPositive

    PeterPositive Senior Member

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    A little B2 and B3 would be necessary to support the folate cycle, so the essentials would be:
    B9 (methylfolate) supported by B2 and B3 (NAD) +
    B12 (methylcobalamin) +
    B6 (usually recommended)
     
  3. minkeygirl

    minkeygirl But I Look So Good.

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    I know about the methylfolate and B12. What I am asking about is it ok to take B5 and B6 in the mornings?

    What is NAD? That isn't on anything I've seen re: the Deadlock Quartet. Also, I can't take the B's that are the orange color. Even thinking about it makes me gag.

    I can't grasp how methylation works so I pretty need someone to lead me like a lamb to the slaughter.
     
  4. sregan

    sregan Senior Member

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    NAD is active (coenzymated) B3, NADH is even more active B3
     
  5. minkeygirl

    minkeygirl But I Look So Good.

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    @sregan, thanks. Are those the ones that are orange and have the nasty taste? if so I have to pass.
     
  6. PeterPositive

    PeterPositive Senior Member

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    The one you are referring to is B2, riboflavin, which gives the characteristic yellow/orange color to tablets and also causes the orange urine.

    If you can't take B2 supplements maybe you could at least make sure your diet contains enough B2-rich foods.
    http://www.healthaliciousness.com/articles/foods-high-in-riboflavin-vitamin-B2.php
     
  7. PeterPositive

    PeterPositive Senior Member

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    I don't see any problem with that.

    B2 and B3 are indispensable for the MTHFR enzyme to do its work:
    http://www.nchpeg.org/nutrition/index.php?option=com_content&view=article&id=452&tmpl=component

    https://books.google.it/books?id=9y-iHQ0NLjMC&pg=PA80&lpg=PA80&dq=NADPH in methylation cycle&source=bl&ots=K_rrCARc6v&sig=Uuxhjh8D5bBBwoTab8PxPCn68Q8&hl=en&sa=X&ei=Xz6uVP3tN4r8UMG_gaAI&ved=0CFcQ6AEwBw#v=onepage

    In general, that's why a basic B complex is recommended, along with B12 and B9.

    cheers
     
  8. minkeygirl

    minkeygirl But I Look So Good.

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    I can't read easily, and definitely not the SMP so I don't remember anyone talking about those B's but that doesn't mean it's not there. I know they are not in the deadlock quartet Freddd talked about.

    I have to add things very slowly so we'll see how it goes.
     
  9. minkeygirl

    minkeygirl But I Look So Good.

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    I had a horrible reaction to B6. I felt more fogged than usual then about the time it started to "wear off" I started yawning like crazy and then crashed.

    This is the same thing that happened with pregnenolone except I felt good before the crash.
     
  10. PeterPositive

    PeterPositive Senior Member

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    Maybe too much B6? How much did you take?
     
  11. minkeygirl

    minkeygirl But I Look So Good.

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    I think 50 mgs. Thought that was low.
     
  12. PeterPositive

    PeterPositive Senior Member

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    Au contraire :) That's a lot.
    Few people need that much. And starting with such dose is an overkill, especially if you are sensitive.
    B6 should be started at 2-5mg, then gradually bringing it up to, say, 10mg. (500% RDA)

    More than that can be used in stubborn homocysteinuria, specific B6 deficiencies, pyroluria...
     
  13. minkeygirl

    minkeygirl But I Look So Good.

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    Well when I looked this seemed like the lowest dose. I can crush it and take a lower dose that way. Not a big deal.

    Don't talk to me about homcystenadlk;dfljk;ldjf;ldjkkl etc, it makes about as much sense to me as what I just typed. I don't understand, can't understand and don't try to understand science.
     

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