Hello, I'm thinking about adding in some P5P (pyridoxal-5'-phosphate/active form of B6) in my methylation regime as I've heard it being recommended for MTHFR A1298c gene mutation, as I have. Apparently it's also involved in a whole lot of other processes regarding driving the methylation cycle, like creating neurotransmitters serotonin, dopamine and norepinephrine. Also got potential for lowering homocysteine which would benefit me (have high homocysteine). I do not know if I really got a deficiency, but possibly symptoms is pointing to that for sure so figured I give it a try. Also read some scary things about overdosing on it, B6 overload could cause neuropathy, nerve damage in brain etc. Anyone got something to share regarding P-5-P? Cant seem to find much information on it here and dont see it recommended as a part of a methylation protocol? Is there any clear risks or something that could negativly affect methylation?