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What about inherited immune deficiencies?

Discussion in 'Latest ME/CFS Research' started by richvank, Sep 19, 2012.

  1. Jenny

    Jenny Senior Member

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    London
  2. Kimsie

    Kimsie Senior Member

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    In the past 2 months I have been forming a new theory about certain chronic illnesses, such as ME/CFS, MS, Alzheimer's, schizophrenia, depression and probably many others, and this post by Rich is mostly right on the nose with what I think about the cause of these illnesses. I first learned about methylation and watched his videos right after he died, I sure wish he was still alive to talk this over with.

    I think he was a little off, though. I think this is really about Glutathione Depletion--Kreb's Cycle/Electron Transport Chain Block rather than a block in the methylation cycle. Of course the methylation cycle can be involved. But the real problem is in the Kreb's cycle and the electron transport chain which is the source of most of our energy, plus a critical problem with sulfite oxidase, which is located between the mitochondrial membranes and interacts with the electron transport chain.

    Edit: The first report about folate was in 2010. I got it mixed up with another study, so I am editing this paragraph. Folate is used in the synthesis and/or repair of iron-sulfur clusters. This new information puts a different perspective on supplementation with folate and how it helps energy production because the electron transport chain is full of iron-sulfur clusters, and if your iron-sulfur clusters are being oxidized your electron transport chain will not be working very well, and you probably won't have energy. (I say probably because there is a way that you can have energy - but it just leads to more problems like MS or mental illness) What can oxidize those iron-sulfur clusters? Hydrogen peroxide (H2O2). What gets rid of H2O2? Glutathione.

    My theory is that it is not really so very important what your genetics are; they could be a problem, but people without any particular genetic problems can be affected depending on various environmental factors at the time the problem begins. What matters is that if a person has enough stress of some kind, whether from a virus or something else, or several stressors at once and the body can not deal with the oxidative stress through glutathione - in other words can't make or reactivate enough glutathione, this can cause a cascade of events that leads to a vicious cycle and perpetuates the problem after the original cause is gone. Sometimes there are no symptoms for years after the cascade happens, so the illness might not seem to be connected with any event. This would be the case in people with neurodegenerative illnesses and maybe some others, too.

    I am planning to talk about the cascade in another post but this is probably enough for one post. I guess I have a tendency to put too much into one post and be too technical.

    Why am I so interested in this? Because I have one son with depression and another with schizophrenia. They both became ill when they had mono and I think this is what is causing their illnesses. I am trying to find a way to break the vicious cycle. I am currently testing something. If it works I will certainly post about it. Thanks, Kim
     
    Last edited: Sep 30, 2014
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  3. katcoff

    katcoff

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    I had a tonsillectomy at age two and had a lot of trouble with infectious diseases as a youth. I got what I thought was mono at age 21 in a flu-like illness, but it became chronic CFS/ME for the next four+ decades. Since having ME/CFS I get exhausted and have pressure headaches etc., but seldom get sick, although I had bacterial pneumonia a few years ago. My symptoms have decreased a bit over time.
    Two other people I knew in my college got the same illness as they described their symptoms, but they recovered after a few months.
    I recently contacted Dr. Henderson who was going to call my doctor re Valtrex treatments, as he has seen good results with it (see Cort Johnson Health Rising blog), although I don't really expect anything to come of it.
    Thanks for your interest.
     

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