The problem with prednisone is that it is a medium-length acting steroid...this means that you end up with levels higher than optimal at times when it is undesirable ie at night when you would prefer to be sleeping. Most people with adrenal issues do best on hydrocortisone. It is a short acting steroid that can be dosed across the day to mimic the natural diurnal variation. However, some people with a history of infection may need a combination of longer and shorter acting steroids to keep levels steady due to the increased need caused by the infections. 2 mg of prednisone is roughly equivalent to 10 mg of HC. Depending on your adrenal status, this might actually make you feel worse by suppressing more steroid production than you are replacing. I think the 25 mg of pred once a week is nuts. Have you had an adrenal saliva test? Any adrenal testing at all? I would definitely not embark on a long-term steroid protocol before doing appropriate testing. High and low cortisol sometimes overlap symptoms-wise and it is important to know what you are trying to treat first. Keep in mind that steroids should be weaned rather than stopped abruptly in order to give your own adrenals a chance to recover. Testing should be done after no steroid use for at least 2-4 weeks.