I may be out in left field asking about this because this may not have anything to do with increased methylation but I'll see if any of you have any input on this anyway. I have had a partially obstructed nasal passage in my right nostril for quite some time. I rarely get sinus issues other than when I get a cold and it's not often that I get a cold. Just recently, and this happened twice on seperate occasions, I started getting sinus drainage ONLY from this right nostril. I can't figure out why it would happen only in my one nostril that has been partially blocked? Would this have anything to do with increasing methylation and/or adding any of the cofactor supplements in something working on trying to clear up this obstruction? I have no idea but I find this very strange in that I only got sinus drainage from only this one nostril and this is the first time that this has ever happened. I'm quite perplexed but if something is working on clearing this nostril up I am all for it. Anyone have a clue about this because I sure don't?